Under the EU REACH regulation (EC No. 1907/2006) it is required for substances which are produced and/or imported in tonnages at or above 10 tons per year and which have been identified as being "hazardous" (according to 67/548/EEC), to develop so-called "exposure scenarios".  An integral part of these exposure scenarios is the estimation of exposure for all relevant routes. For workers, the inhalation and dermal exposure route are commonly assumed to be relevant. The relevant ECHA guidance (PART D, R.12 & R.14) foresees to assess occupational exposure on the basis of process categories (PROC). These PROCs may be seen as surrogates for specific process steps/tasks/workplaces.



To assess occupational exposure, the guidance foresees a "tiered approach". For the 1st tier, it is proposed to use so-called "screening tools". These tools provide conservative estimates of exposure and are meant to identify (screen) unproblematic PROCs in order to save resources to be allocated to PROCs for which higher tier assessments are needed.



On behalf of EUROMETAUX, EBRC has developed a tool for the estimation and assessment of substance exposure (MEASE version 1) which combines approaches from the EASE expert system, from the ECETOC TRA tool and from the health risk assessment guidance for metals (HERAG). It aims on providing a 1st tier screening tool for the estimation of occupational inhalation and dermal exposure to metals and inorganic substances.



For inhalation exposure, the tool follows the PROC approach of the ECETOC TRA tool and selects initial exposure estimates from three fugacity classes (low, medium, high). The fugacity classes are defined based on the physical form, the melting point of the metal, the temperature of the process, the vapour pressure and the selected PROC. The initial exposure estimates for PROCs 21-27a in MEASE are based on measured data from the metals industry.



For dermal exposure, MEASE is based on the system of exposure bands of the broadly used EASE system. However, the generated exposure estimates are based on measured data from several metals, collated and plotted against the EASE exposure classes in the "dermal fact sheet" of the HERAG project.



MEASE version 1.02.01 can be downloaded free of charge from



MEASE (version 1.02.01) has been broadly used by the metals’ industry for chemical safety assessments in REACH registration dossiers during the last years.



Continuous updating of MEASE on regular basis was foreseen after publishing the first version of MEASE in order to reflect comments from users of the tool received, to provide reasonable exposure estimates reflecting up-to-date monitoring data and to also reflect updates of ECHA guidance. Also, since 2010, ECHA’s CHEmical Safety Assessment and Reporting tool (Chesar) aiming at facilitating the drafting of ES and CSR has been developed. Finally, MEASE has been included in the ETEAM project (Evaluation of Tier 1 Exposure Assessment Models under Reach), a project validating and comparing the different REACH Tier 1 exposure assessment models in terms of their determinants, scope of application, functionality and user-friendliness.



To reflect the outcomes of the ETEAM project, increase user friendliness and to enable functional interactions with Chesar, MEASE needs now to undergo substantial revision and several additional features need to be implemented. MEASE 2 will be developed as a standalone-software and should become downloadable Q2 2016


MEASE 2 is coming soon (end of January 2018)



Latest update : 28 December 2017